I have made a couple all fleece, pieced quilts. I don't have photos but they work out pretty well. You can't be too insistent on perfect corners... the stuff shifts a bit, but it looks good. I sewed both. Whatever thread I had. I think the default stitch is 2.2 and that's what I used.
My suggestion is that you should keep the quilting simple. That beast will be heavy and hard to handle.
I made what would have been a gorgeous yellow brick road quilt from a bunch of different fleece prints and solids. He saw it laid out before I put the rows together and said "not big enough". As a result, I went back and put big solid strips between the rows and then surrounded thewhole thing with a checkerboard type arrangement, trying to get it big enough.
He's 6"2' and carries the thing around like a blankie, wrapping up in it when he first get up or if he's going to watch a movie or something.
The fleece is pretty forgiving and simple lines sewn through look good. But don't make yourself crazy trying to match points. I think something like yellow brick road or Turning 20 or something like that would be good. Big, easy to put together and not too fussy.
Good luck, and I'd love to ssee photos when you're done.
Sunny