Just a few suggestions -- bundle things as reasonable so you get rid of more little things. With smallish pieces of quilting fabric, I have found that folding things nicely to about 6" x 8" or fat-quarter size, you can put the smaller pieces into the stacks with the larger bits, and then tie it all up with string or ribbon. Add a label along the lines of "Quilt fabric treasures! 100% cotton! clean!" As bundles that are tied, people won't go pawing through each bit, but buy bundles. For larger pieces -- such as more than 1/2 yard -- it is helpful to have amounts on the labels.
Don't let anybody into your house! Never! You do NOT need to provide bathroom service or let people into your kitchen for water to take pills! Lie if it makes you feel better -- the dog isn't friendly, the kid is throwing up, whatever. But do NOT let anybody inside to help themselves to your things or to case your house! Yes, it happens . . . Tell the "gotta pee" and "gotta take my pill" folks where the closest fast food restaurant or gas station is.
Also re security -- sad that we need it, but we do -- NEVER leave your cash box or money unattended, and have an extra person or two with you to help people, to be friendly, and to keep an eye out.
Have a lot of plastic bags with handles handy for people -- the kind from the grocery store are great!
Resolve that once an item is outside for sale that it is NOT coming back into your house no matter what! Pack up leftovers in extra bags, put them into your car, and get them to the Salvation Army, Goodwill, or other charity at the first of next week.
Finally, go to the bank and get a LOT of $1 bills and several rolls of quarters. (We always get about $200 that way.) The bank will be very nice about taking all of your extras back after the sale.
Have a great sale!